Surface expression of the immunotherapeutic target GD2 in osteosarcoma depends on cell confluency.

Malena WiebelSareetha KailayangiriBianca AltvaterJutta MeltzerKay GrobeSabine KupichClaudia Rossig

Published in: Cancer reports (Hoboken, N.J.) (2021)

Expression of GD2 in OS cell lines is highly variable and associated with increasing cell confluency in vitro. Strategies for selective upregulation of GD2 are needed to enable effective therapeutic targeting of this antigen in OS.

Keyphrases

poor prognosis
single cell
cell therapy
long non coding rna
binding protein
signaling pathway
drug delivery