Carbonic anhydrase IX stratifies patient prognosis and identifies nodal status in animal models of nasopharyngeal carcinoma using a targeted imaging strategy.
Wenhui HuangKun WangWeiyuan HuangZicong HeJingming ZhangBin ZhangZhiyuan XiongKelly McCabe GillenWenzhe LiFeng ChenXing YangShuixing ZhangZhenyu ZhangPublished in: European journal of nuclear medicine and molecular imaging (2022)
CAIX remarkably expresses in human NPCs and stratifies patient prognosis. In preclinical studies, CAIX-800-based imaging successfully identifies occult LNMs and tracks early stage of pathological ENE. This attractive method shows potential in clinic, allowing medical workers to longitudinally monitor nodal status and helping to reduce unnecessary nodal biopsy for patients with NPC. The schematic diagram for the study. CAIX, carbonic anhydrase IX; NPC, nasopharyngeal carcinoma; US, ultrasonography; sPA, spectroscopic photoacoustic.
Keyphrases
- early stage
- high resolution
- lymph node
- neoadjuvant chemotherapy
- case report
- genome wide
- endothelial cells
- healthcare
- primary care
- magnetic resonance imaging
- fluorescence imaging
- cancer therapy
- magnetic resonance
- dna methylation
- computed tomography
- ultrasound guided
- cell therapy
- drug delivery
- sentinel lymph node
- mass spectrometry
- climate change
- induced pluripotent stem cells
- radiation therapy
- human health
- pluripotent stem cells
- fine needle aspiration
- rectal cancer