Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition.
Stephanie A RennaXuefei ZhaoSatya P KunapuliPeisong MaMichael A HolinstatMatthew B BoxerDavid J MaloneyJames V MichaelSteven E McKenziePublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
These data demonstrate for the first time the need for dual platelet receptor (PAR [protease-activated receptor] and FcγRIIA) stimulation for fibrin formation in HIT in vivo. These results extend our understanding of HIT pathophysiology and provide a scientific rationale for targeting the procoagulant phenotype as a possible therapeutic strategy in HIT.