PTEN Lipid Phosphatase Activity Suppresses Melanoma Formation by Opposing an AKT/mTOR/FRA1 Signaling Axis.

Xiaonan Xu Ilah Bok Neel Jasani Kaizhen Wang Manon Chadourne Nicol Mecozzi Ou Deng Eric A Welsh Fumi Kinose Uwe Rix Florian A Karreth

Published in: Cancer research (2024)

PTEN suppresses melanoma predominantly through its lipid phosphatase function, which when lost, elevates FRA1 levels through AKT/mTOR signaling to promote several aspects of melanomagenesis.

Keyphrases

cell proliferation
signaling pathway
pi k akt
fatty acid
skin cancer
protein kinase