Expression of palladin is associated with disease progression in metastatic high-grade serous carcinoma.

Ben DavidsonAnnika Jøntvedt BockArild HolthDag Andre Nymoen

Published in: Cytopathology : official journal of the British Society for Clinical Cytology (2020)

PALLD mRNA is overexpressed in HGSC compared to MM effusions, and its protein product is overexpressed in post-chemotherapy compared to pre-chemotherapy HGSC effusions, suggesting upregulation along tumour progression. The presence of this molecule in HGSC effusions, at the mRNA or the protein level, is unrelated to disease outcome.

Keyphrases

high grade
binding protein
poor prognosis
low grade
locally advanced
squamous cell carcinoma
protein protein
small cell lung cancer
amino acid
small molecule
cord blood