Nectin-2 Expression on Malignant Plasma Cells Is Associated with Better Response to TIGIT Blockade in Multiple Myeloma.

Ester LozanoMari-Pau MenaTania DíazBeatriz Martin-AntonioSheila LeónLuis-Gerardo Rodríguez-Lobato Marta GarroteMaria Teresa CibeiraJoan BladéAleix PratLaura RosiñolCarlos Fernández de Larrea

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

TIGIT blockade efficiently reinvigorated peripheral T cells from patients with multiple myeloma. However, in the BM, the efficacy of blocking anti-TIGIT mAb to achieve tumor cell death may depend on the expression of TIGIT and nectin-2, becoming potential predictive biomarkers for identifying patients who may benefit from TIGIT blockade.

Keyphrases

multiple myeloma
cell death
poor prognosis
cell cycle arrest
induced apoptosis
binding protein
long non coding rna
cell proliferation
endoplasmic reticulum stress