Noninvasive Quantification of Radiation-Induced Lung Injury using a Targeted Molecular Imaging Probe.
Eric AbstonIris Y ZhouJonathan A SaengerSergey ShuvaevEman A AkamShadi A EsfahaniLida P HaririNicholas J RotileElizabeth CrowleySydney B MontesiValerie HumbletGrae ArabaszCiprian CatanaFlorian J FintelmannPeter CaravanMichael LanutiPublished in: medRxiv : the preprint server for health sciences (2023)
These findings support the ability of a molecular imaging probe targeted at type 1 collagen to detect RILI in preclinical models and human disease, suggesting a role for targeted molecular imaging of collagen in the assessment of RILI. Clinical trial registered with www.clinicaltrials.gov ( NCT04485286 , NCT03535545 ).