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Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features.

Kamila OstrowskaPatryk NiewinskiIgor PiotrowskiJulia OstapowiczSabina KoczotWiktoria Maria SuchorskaPaweł GolusinskiMichal Mateusz MasternakWojciech Golusiński
Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2024)
Our primary study indicates that SASP expression may be associated with some clinicopathological features. However, a more detailed study is needed to present specific role of senescence-related mechanism and SASPs especially in tumor therapy response and in relation to the patient's immune system condition.
Keyphrases
  • dna damage
  • endothelial cells
  • poor prognosis
  • stress induced
  • stem cells
  • case report
  • oxidative stress
  • mesenchymal stem cells
  • bone marrow
  • smoking cessation
  • replacement therapy