Therapeutic and safety outcomes of intracoronary nicardipine in coronary artery disease patients: a systematic review.
Syeda Tayyaba RehanLaiba ImranAqsa SalimSyed Owais JavedLaiba ImranHassan Ul HussainJawad AhmedFarah YasminMd Saiful IslamMuhammad Sohaib AsgharPublished in: Future cardiology (2023)
Aim: This systematic review aimed to shed light on the efficacy of intracoronary (IC) nicardipine in treating no reflow with CAD undergoing revascularization. Methods: Literature search was performed on databases with following eligibility criteria: adult patients with CAD; clinical trials or observational studies; IC nicardipine as intervention; therapeutic and safety outcome reported. Results: A total of 1249 papers were yielded during the literature search. Of these, 11 studies were finalized for this systematic review. Complete restoration of TIMI 3 flow was observed in 98.6% of the patients receiving IC nicardipine. A significant increase in the CBF after infusion of IC nicardipine (p < 0.05) was also observed. Conclusion: IC nicardipine significantly increases CBF and decreases coronary vascular resistance.
Keyphrases
- systematic review
- coronary artery disease
- percutaneous coronary intervention
- coronary artery bypass grafting
- clinical trial
- meta analyses
- end stage renal disease
- st elevation myocardial infarction
- newly diagnosed
- randomized controlled trial
- chronic kidney disease
- cardiovascular events
- peritoneal dialysis
- ejection fraction
- coronary artery
- type diabetes
- heart failure
- transcatheter aortic valve replacement
- patient reported
- machine learning
- artificial intelligence
- atrial fibrillation
- acute coronary syndrome
- insulin resistance
- patient reported outcomes