Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.

Jin-Gu LeeWeiliang HuangHangnoh LeeJoyce van de LeemputMaureen A KaneZhe Han

Published in: Cell & bioscience (2021)

Our study revealed Orf6 as a highly pathogenic protein from the SARS-CoV-2 genome, identified its key host interacting proteins, and Selinexor as a drug candidate for directly targeting Orf6 host protein interaction that leads to cytotoxicity.

Keyphrases

sars cov
respiratory syndrome coronavirus
protein protein
binding protein
emergency department
cancer therapy
gene expression
small molecule
cystic fibrosis
protein kinase
electronic health record