Genomic Features of Lung-Recurrent Hormone-Sensitive Prostate Cancer.

Nicolette M FonsecaKim Van der Eecken Cameron Herberts Sofie L J Verbeke Sarah W S NgNicolaas LumenElie RitchAndrew J Murtha Nicolette M FonsecaElena SchönlauLisa MorisJo Van Dorpe Matti Annala Alexander W Wyatt Piet Ost

Published in: JCO precision oncology (2022)

In this retrospective hypothesis-generating study, we observed indolent genomic etiology in selected lung-recurrent mHSPC, cautioning against grouping these patients together with liver or bone-predominant mHSPC. Although our data do not generalize to all patients with lung metastases, the results encourage prospective efforts to stratify lung-recurrent mHSPC by genomic features.

Keyphrases

prostate cancer
copy number
end stage renal disease
newly diagnosed
radical prostatectomy
prognostic factors
electronic health record
cross sectional
bone mineral density
machine learning
quality improvement
dna methylation
big data
soft tissue
body composition
patient reported outcomes
artificial intelligence