Perinatal Propionate Supplementation Protects Adult Male Offspring from Maternal Chronic Kidney Disease-Induced Hypertension.
You-Lin TainChih-Yao HouGuo-Ping Chang-ChienSu-Fan LinChien-Ning HsuPublished in: Nutrients (2022)
Emerging evidence supports that early-life disturbance of gut microbiota has an impact on adult disease in later life. Offspring hypertension can be programmed by maternal chronic kidney disease (CKD). Conversely, perinatal use of gut microbiota-targeted therapy has been implemented to reverse programming processes and prevent hypertension. Short-chain fatty acids (SCFAs), the major gut microbiota-derived metabolites, can be applied as postbiotics. Propionate, one of predominant SCFAs, has been shown to have antihypertensive property. We examined whether perinatal propionate supplementation can prevent offspring hypertension induced by maternal CKD. CKD was induced by chow supplemented with 0.5% adenine for 3 weeks before pregnancy. Propionate (P) was supplemented at 200 mmol/L in drinking water during pregnancy and lactation. Male offspring were divided into four groups ( n = 7-8/group): control, CKD, control+propionate (CP), and CKD+propionate (CKDP). Maternal CKD-induced offspring hypertension was reversed by perinatal propionate supplementation. The protective effects of perinatal propionate treatment were related to increased propionate-generating bacteria Clostridium spp. and plasma propionate level, increased expression of renal G protein-coupled receptor 41 (GPR41, a SCFA receptor), augmentation of α-diversity, and shifts in gut microbiota composition. In summary, our results highlight that maternal CKD-induced offspring hypertension can be prevented by the use of gut microbial metabolite SCFAs in early life, which could shed light on the prevention of the current hypertension pandemic.
Keyphrases
- chronic kidney disease
- blood pressure
- end stage renal disease
- early life
- high fat diet
- drinking water
- pregnant women
- pregnancy outcomes
- birth weight
- high glucose
- fatty acid
- hypertensive patients
- diabetic rats
- sars cov
- drug induced
- coronavirus disease
- type diabetes
- risk assessment
- oxidative stress
- binding protein
- microbial community
- insulin resistance
- endothelial cells
- heavy metals
- human milk
- health risk assessment
- skeletal muscle
- replacement therapy