Establishment of a novel ER-stress induced myopia model in mice.
Longdan KangShin-Ichi IkedaYajing YangHeonuk JeongJunhan ChenYan ZhangKazuno NegishiKazuo TsubotaToshihide KuriharaPublished in: Eye and vision (London, England) (2023)
We have demonstrated that ER stress in the sclera is involved in myopia progression. Tm eyedrops induced myopic changes, loosening of the scleral collagen and decreased expression of collagen I. This process may be associated with ER stress in the sclera, which upregulates the expression of MMP2 leading to collagen degradation.