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Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens.

Verónica MixãoJuan Carlos Nunez-RodriguezValentina Del OlmoEwa KsiezopolskaEster SausTeun BoekhoutAttila GacserToni Gabaldon
Published in: BMC biology (2023)
Our results suggest that genetic drift is the prevailing force shaping LOH patterns in these hybrid genomes. Moreover, the observed LOH patterns suggest that these are likely not the result of continuous accumulation of sporadic events-as expected by mitotic repair of rare chromosomal breaks-but rather of acute episodes involving many LOH events in a short period of time.
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