Safety and Efficacy of Tenecteplase in Older Patients With Large Vessel Occlusion: A Pooled Analysis of the EXTEND-IA TNK Trials.
Vignan YogendrakumarLeonid ChurilovPeter J MitchellTimothy J KleinigNawaf YassiVincent N ThijsTeddy Y WuDarshan G ShahFelix Chun Fai NgHelen M DeweyTissa WijeratneBernard YanPatricia M DesmondMark W ParsonsGeoffrey Alan DonnanStephen M DavisBruce C V Campbellnull nullPublished in: Neurology (2022)
This study provides Class II evidence that tenecteplase 0.25 mg/kg given before endovascular therapy in patients >80 years old with large vessel occlusion stroke is associated with better functional outcomes at 90 days and reduced mortality when compared to tenecteplase 0.40 mg/kg or alteplase 0.90 mg/kg.