Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage.
Shukun WanXiaoqing WangWeina ChenManli WangJingsong ZhaoZhongyan XuRong WangChenyang MiZhaodian ZhengHuidong ZhangPublished in: Particle and fibre toxicology (2024)
Exposure to PS-NPs activated Bcl-2/Cleaved-caspase-2/Cleaved-caspase-3, leading to excessive apoptosis in human trophoblast cells and in mice placental tissues, further inducing miscarriage.
Keyphrases
- induced apoptosis
- cell cycle arrest
- cell death
- endoplasmic reticulum stress
- high dose
- oxidative stress
- endothelial cells
- signaling pathway
- low dose
- cell proliferation
- gene expression
- pi k akt
- stem cell transplantation
- induced pluripotent stem cells
- weight gain
- pluripotent stem cells
- type diabetes
- skeletal muscle
- physical activity