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Diboron reagents in the deoxygenation of nitrones.

Emily L VargasMario FrancoInés AlonsoMariola TortosaMaría Belén Cid
Published in: Organic & biomolecular chemistry (2023)
B 2 nep 2 efficiently promotes the N-O cleavage of nitrones to form imines in very high yields via a simple, efficient, sustainable, functional group tolerant and scalable protocol. The reaction occurs in the absence of additives through a concerted mechanism. We demonstrated that DMPO and TEMPO, typically used as radical traps, are also deoxygenated by diboron reagents, which demonstrates their limitation as mechanistic probes.
Keyphrases
  • small molecule
  • randomized controlled trial
  • dna binding
  • ionic liquid
  • living cells
  • fluorescence imaging
  • single molecule