Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs.

Alexandru Emil MateiChih-Wei ChenLisa KiesewetterAndrea-Hermina GyörfiYi-Nan LiThuong Trinh-MinhXiaohan XuCuong Tran ManhToin van KuppeveltJan HansmannAstrid JüngelLarissa Valor-MéndezFlorian Groeber-BeckerJörg H W Distler

Published in: Annals of the rheumatic diseases (2019)

Our data provide evidence that vascularised skin equivalents can replicate key features of fibrotic skin and may serve as a platform for evaluation of antifibrotic drugs in a pathophysiologically relevant human setting.

Keyphrases

soft tissue
wound healing
endothelial cells
high throughput
machine learning
idiopathic pulmonary fibrosis
big data
drug induced
artificial intelligence
pluripotent stem cells