Unraveling the Clinical Relevance of Ferroptosis-Related Genes in Human Ovarian Aging.
Pei-Hsuan LinChia-Jung LiLi-Te LinWan-Ping SuJim Jinn-Chyuan SheuZhi-Hong WenJiin-Tsuey ChengKuan-Hao TsuiPublished in: Reproductive sciences (Thousand Oaks, Calif.) (2023)
Ferroptosis, a recently discovered form of cell death, has been implicated in various diseases. However, the genetic relationship between ferroptosis and ovarian aging has not been thoroughly investigated through informatics analysis. In this study, we conducted bioinformatics analysis using ovarian aging and ferroptosis datasets to identify potential ferroptosis-related genes using R software. The expression levels of these genes at different ages were analyzed using the GTEx public database. To validate these findings at the genetic level, we performed clinical infertility biopsies. Bioinformatics analysis of a mouse ovary dataset revealed significantly higher expression of Tfrc, Ncoa4, and Slc3a2 in the aging group compared to the young group, while Gpx4 showed the opposite pattern. Consistent results were observed in biopsies from clinically aged infertile patients. This study is the first to identify a ferroptosis-related gene associated with ovarian aging, highlighting its potential as a diagnostic biomarker.
Keyphrases
- cell death
- genome wide
- cell cycle arrest
- poor prognosis
- end stage renal disease
- ejection fraction
- endothelial cells
- healthcare
- newly diagnosed
- chronic kidney disease
- gene expression
- mental health
- binding protein
- peritoneal dialysis
- dna methylation
- ultrasound guided
- skeletal muscle
- adverse drug
- insulin resistance
- single cell
- single molecule
- drug induced
- transcription factor
- genome wide analysis