MultiSCRIPT-Cycle 1-a pragmatic trial embedded within the Swiss Multiple Sclerosis Cohort (SMSC) on neurofilament light chain monitoring to inform personalized treatment decisions in multiple sclerosis: a study protocol for a randomized clinical trial.

Perrine JaniaudChiara ZeccaAnke SalmenPascal BenkertSabine SchädelinAnnette OrlethLilian DemuthAleksandra Maleska MaceskiCristina GranzieraJohanna OechteringDavid LeppertTobias DerfussLutz AchtnichtsOliver FindlingPatrick RothPatrice LaliveMarjolaine UginetStefanie MüllerCaroline PotRobert HoepnerGiulio DisantoClaudio GobbiLeila RooshenasMatthias SchwenkglenksMark J LambirisLudwig KapposJens KuhleÖzgür YaldizliLars G Hemkens

Published in: Trials (2024)

ClinicalTrials.gov NCT06095271. Registered on October 23, 2023.

Keyphrases

multiple sclerosis
study protocol
white matter
cerebrospinal fluid
phase iii
randomized controlled trial
phase ii
combination therapy
open label
replacement therapy