Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy.

Pu ZhangMengxin XuJie DingJunyi ChenTaiping ZhangLi HuoZhibo Liu

Published in: European journal of nuclear medicine and molecular imaging (2021)

This proof-of-concept study validates the hypothesis that conjugation of albumin binders may shift the pharmacokinetics and enhance the tumor uptake of FAPI-based radiopharmaceuticals. This could be a general strategy to transform the diagnostic FAP-targeted radiopharmaceuticals into their therapeutic pairs.

Keyphrases

fatty acid
cancer therapy
early stage
photodynamic therapy
radiation therapy
locally advanced
radiation induced
protein protein
squamous cell carcinoma
amino acid
small molecule
binding protein
rectal cancer