Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation.
Desheng WangMarta T GomesYanfei MoClare C ProhaskaLu ZhangSarvesh ChelvanambiMatthias A ClaussDongfang ZhangRoberto F MachadoMingqi GaoYang BaiPublished in: International journal of molecular sciences (2023)
Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human endogenous retrovirus K(HERV-K), and human immunodeficiency virus (HIV), in part due to acute and chronic inflammation. In this review, we discuss the connections between HERV-K, HIV, SARS-CoV-2, and PAH, to stimulate research regarding new therapeutic options and provide new targets for the treatment of the disease.
Keyphrases
- sars cov
- human immunodeficiency virus
- respiratory syndrome coronavirus
- antiretroviral therapy
- pulmonary arterial hypertension
- hepatitis c virus
- hiv infected
- hiv positive
- pulmonary hypertension
- oxidative stress
- polycyclic aromatic hydrocarbons
- hiv aids
- endothelial cells
- hiv testing
- coronavirus disease
- pulmonary artery
- induced pluripotent stem cells
- pluripotent stem cells
- men who have sex with men
- liver failure
- multiple sclerosis
- south africa
- drug induced
- magnetic resonance imaging
- coronary artery
- acute respiratory distress syndrome