State-wide utilization and performance of traditional and cell-free DNA-based prenatal testing pathways: the Victorian Perinatal Record Linkage (PeRL) study.
Anthea C LindquistLisa HuiAlice PoultonE KluckowB HutchinsonM D PertileL BonacquistoL GugasyanA KulkarniJ HarrawayA HowdenR McCoyF Da Silva CostaM MenezesR Palma-DiasD NisbetN MartinM BethuneZ PoulakisJ HallidayPublished in: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2021)
Our state-wide record-linkage analysis delineated the utilization and clinical performance of the multitude of prenatal screening pathways available to pregnant women. The sensitivity of cfDNA for T21, T18 and T13 was clearly superior to that of CFTS. While there was no statistically significant difference in the residual risk of any major chromosomal abnormality after a low-risk CFTS or cfDNA result, there were fewer live infants diagnosed with a major chromosomal abnormality in the cfDNA cohort. These data provide valuable population-based evidence to inform practice recommendations and health policies. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Keyphrases
- human immunodeficiency virus
- pregnant women
- hepatitis c virus
- hiv testing
- public health
- healthcare
- hiv infected
- copy number
- genome wide
- primary care
- pregnancy outcomes
- electronic health record
- big data
- randomized controlled trial
- health information
- men who have sex with men
- gene expression
- risk assessment
- climate change
- human health
- dna methylation
- machine learning
- social media