Peri-procedural myocardial infarction: what is in a definition?

Peri-procedural myocardial infarction (PMI) is an important outcome measure in several trials. However, there is no consensus regarding the definition of PMI. There is significant variability in terms of biomarkers used, the threshold values, the requirement for additional supporting evidence, and even the duration until which PMI can be said to occur. This lack of clarity leads to inappropriate comparisons between trials. Besides, the outcome of a trial and the inferences drawn are completely altered by using a different definition. Thus, there is a pressing need to formulate a uniform definition for PMI in future studies.