The clinical importance of the host anti-tumour reaction patterns in regional tumour draining lymph nodes in patients with locally advanced resectable gastric cancer: a systematic review and meta-analysis.

Elzbieta BudginaiteMaximilian KloftSander M J van KuijkPedro A CanaoLoes F S KooremanAlexander J PenningsDerek R MageeHenry C WoodruffHeike I Grabsch

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2023)

This systematic review suggests that sinus histiocytosis and paracortical hyperplasia in regional tumour-negative lymph nodes may provide additional prognostic information for gastric and oesophageal cancer patients. Further studies are needed to better understand the lymph node reaction patterns and explore their impact of chemotherapy treatment and immunotherapy efficacy.

Keyphrases

lymph node
locally advanced
neoadjuvant chemotherapy
systematic review
rectal cancer
sentinel lymph node
squamous cell carcinoma
radiation therapy
phase ii study
meta analyses
healthcare
randomized controlled trial
clinical trial
combination therapy
study protocol
case control