New Analogues of Amides and Quinolinones Produced by Streptomyces sp. YIM S01983.
Xia LiDou-Ying ZhuXi-Ru LiuHong-Jian LiuShu-Kun TangLe CaiLi-Xing ZhaoPublished in: Chemistry & biodiversity (2024)
Streptomide (1), a new amide analogue, streptomynone (2), a new quinolinone, and ten known compounds including three aliphatic acids (3-5), two amides (6-7), four cyclic dipeptides (8-11), and an adenosine (12) were isolated from the fermentation broth of Streptomyces sp. YIM S01983 isolated from a sediment sample collected in Bendong Village, Huadong Town, Chuxiong, China. Their structures were determined by analysis of the 1D/2D-NMR and HR-ESI-MS spectra. Compound 12 presented weak antimicrobial activities against Candida albicans and Aligenes faecalis (MIC=64 μg/mL). Compounds 7 and 12 showed weak cytotoxic activity against MHCC97H.
Keyphrases
- candida albicans
- ms ms
- biofilm formation
- high resolution
- south africa
- mass spectrometry
- magnetic resonance
- staphylococcus aureus
- multiple sclerosis
- heavy metals
- saccharomyces cerevisiae
- molecular docking
- solid state
- protein kinase
- polycyclic aromatic hydrocarbons
- lactic acid
- pseudomonas aeruginosa
- molecular dynamics