Persistent epigenetic alterations in transcription factors after a sustained virological response in hepatocellular carcinoma.
Keishi SugimachiHiromitsu ArakiHideyuki SaitoTakaaki MasudaFumihito MiuraKentaro InoueTomonari ShimagakiYohei ManoTomohiro IguchiMasaru MoritaYasushi TohTomoharu YoshizumiTakashi ItoKoshi MimoriPublished in: JGH open : an open access journal of gastroenterology and hepatology (2022)
This study demonstrates that DNA methylation abnormalities, retained after HCV eradication, affect the expression of transcription factors and their target genes. These findings suggest that DNA methylation in SVR patients may be functionally important in carcinogenesis, and could serve as biomarkers to predict HCC occurrence.
Keyphrases
- dna methylation
- genome wide
- transcription factor
- gene expression
- end stage renal disease
- ejection fraction
- poor prognosis
- newly diagnosed
- chronic kidney disease
- hepatitis c virus
- prognostic factors
- peritoneal dialysis
- genome wide identification
- patient reported outcomes
- human immunodeficiency virus
- dna binding
- copy number
- helicobacter pylori infection
- hiv infected patients
- binding protein
- long non coding rna