Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models.
Charles R DunlopYann WallezTimothy Isaac JohnsonSandra Bernaldo de Quirós FernándezStephen T DurantElaine B CadoganAlan LauFrances M RichardsDuncan Ian JodrellPublished in: British journal of cancer (2020)
ATM loss augments replication catastrophe-mediated cell death induced by ATRi/gem and may predict clinical responsiveness to this combination. ATM status should be carefully assessed in tumours from patients with PDAC, since distinction between ATM-low and ATM-null could be critical in maximising the success of clinical trials using ATM expression as a predictive biomarker.