Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification.
Arieke Suzanna Berendina KampstraJacqueline Stephanie DekkersMikhail VolkovAnnemarie L DorjéeLise HafkenscheidAyla C KempersMyrthe van DelftTheresa KisselSanne ReijmGeorge M C JanssenPeter A van VeelenHolger BangTom W J HuizingaLeendert A TrouwDiane van der WoudeRené E M ToesPublished in: Annals of the rheumatic diseases (2019)
Different AMPA responses can emerge from exposure to only a single type of modified protein. These findings indicate that different AMPA responses can originate from a common B-cell response that diversifies into multiple distinct AMPA responses and explain the presence of multiple AMPAs in RA, one of the hallmarks of the disease.