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Influence of probiotic supplementation on the developing microbiota in human preterm neonates.

Niels van BestSonja Trepels-KottekPaul SavelkoulThorsten OrlikowskyMathias W HornefJohn Penders
Published in: Gut microbes (2021)
Our results demonstrate successful transient colonization by probiotic bacteria and a significant influence on the endogenous microbiota with a reduced abundance of bacterial taxa associated with the development of NEC. These results emphasize that probiotic supplementation may allow targeted manipulation of the enteric microbiota and confer a clinical benefit. (Clinical Trial Registry accession number: DRKS/GCTR 00021034).
Keyphrases
  • clinical trial
  • bacillus subtilis
  • endothelial cells
  • low birth weight
  • lactic acid
  • preterm birth
  • cancer therapy
  • open label
  • antibiotic resistance genes
  • gestational age
  • double blind
  • phase ii
  • placebo controlled