Quantification of lectin fluorescence in GNE myopathy muscle biopsies.

Petcharat LeoyklangBradley ClassSatoru NoguchiWilliam A GahlNuria CarrilloIchizo NishinoMarjan HuizingMay Christine Malicdan

Published in: Muscle & nerve (2018)

This quantitative fluorescence method can accurately determine sialylation status of GNE myopathy muscle biopsies. This method is adaptable for expression of other membrane-associated muscle proteins, and may be of benefit for disorders in which therapeutic changes in expression are subtle and difficult to assess by other methods. Muscle Nerve 58: 286-292, 2018.

Keyphrases

skeletal muscle
poor prognosis
late onset
high resolution
mass spectrometry
early onset
peripheral nerve