Reciprocal role of PLAP-1 in HIF-1α-mediated responses to hypoxia.
Masahide TakedachiSatomi YamamotoKohsuke KawasakiJunpei ShimomuraMari MurataChiaki MorimotoAsae HiraiKazuma KawakamiPhan BhongsatiernTomoaki IwayamaKeigo SawadaSatoru YamadaShinya MurakamiPublished in: Journal of periodontal research (2022)
PLAP-1 expression is upregulated under hypoxic conditions through HIF-1α activation. Moreover, hypoxia-induced PLAP-1 expression regulates HIF-1α signaling.