Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data.
Shuang LiKatharina T SchmidDylan H de VriesMaryna KorshevniukCorinna LosertRoy OelenIrene V van Bloklandnull nullHilde E GrootMorris A SwertzPim van der HarstHarm-Jan WestraMonique G P van der WijstMatthias HeinigLude FrankePublished in: Genome biology (2023)
Our co-eQTL results highlight the importance of studying context-specific gene regulation to understand the biological implications of genetic variation. With the expected growth of sc-eQTL datasets, our strategy and technical guidelines will facilitate future co-eQTL identification, further elucidating unknown disease mechanisms.