FIRST-line support for assistance in breathing in children (FIRST-ABC): a master protocol of two randomised trials to evaluate the non-inferiority of high-flow nasal cannula (HFNC) versus continuous positive airway pressure (CPAP) for non-invasive respiratory support in paediatric critical care.

Alvin Richards-BellePeter DavisLaura DrikiteRichard FeltbowerRichard GrieveDavid A HarrisonJulie LesterKevin P MorrisPaul R MounceyMark J PetersKathryn M RowanZia SadiqueLyvonne N TumePadmanabhan Ramnarayan

Published in: BMJ open (2020)

ISRCTN60048867.

Keyphrases

positive airway pressure
obstructive sleep apnea
sleep apnea
clinical trial
young adults
intensive care unit
open label
randomized controlled trial
emergency department
double blind
placebo controlled
acute respiratory distress syndrome
respiratory failure
cell fate