Investigating cellular and molecular mechanisms of neurogenesis in Capitella teleta sheds light on the ancestor of Annelida.
A SurA RenfroP J BergmannNéva P MeyerPublished in: BMC evolutionary biology (2020)
Our data suggest a putative genetic hierarchy with Ct-soxB1 and Ct-neurogenin at the top, followed by Ct-ash1, then Ct-neuroD, and finally Ct-elav1. Comparison of our data with that from Platynereis dumerilii revealed expression of neurogenin homologs in proliferating NPCs in annelids, which appears different than the expression of vertebrate neurogenin homologs in cells that are exiting the cell cycle. Furthermore, differences between neurogenesis in the head versus trunk of C. teleta suggest that these two tissues may be independent developmental modules, possibly with differing evolutionary trajectories.
Keyphrases
- image quality
- dual energy
- computed tomography
- cell cycle
- contrast enhanced
- poor prognosis
- positron emission tomography
- magnetic resonance imaging
- cell proliferation
- genome wide
- magnetic resonance
- electronic health record
- induced apoptosis
- cell death
- cell cycle arrest
- endoplasmic reticulum stress
- pi k akt
- blood brain barrier