IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity.

Jan-Inge BjuneChristine HaugenOddrun GudbrandsenOle P NordbøHans J NielsenVilly VågePål R NjølstadJørn V SagenSimon N DankelGunnar Mellgren

Published in: International journal of obesity (2005) (2018)

Irx5-KO mice were protected from obesity and this can partially be attributed to reduced adipose App and improved mitochondrial respiration. This novel Irx5-App pathway in adipose tissue is a possible therapeutic entry point against obesity.

Keyphrases

insulin resistance
high fat diet induced
adipose tissue
metabolic syndrome
weight loss
high fat diet
type diabetes
skeletal muscle
weight gain
oxidative stress
fatty acid
body mass index
physical activity
wild type