MicroRNA-543 functions as an osteogenesis promoter in human periodontal ligament-derived stem cells by inhibiting transducer of ERBB2, 2.
Y GeJianjia LiY HaoY HuD ChenB WuFuchun FangPublished in: Journal of periodontal research (2018)
Our research confirmed that miR-543 is a promoter of osteogenesis in hPDLSCs, acting by inhibiting its target gene TOB2, which suggests that miR-543 may be a potential therapy for bone loss in periodontitis.
Keyphrases
- bone loss
- stem cells
- cell proliferation
- long non coding rna
- dna methylation
- long noncoding rna
- signaling pathway
- transcription factor
- endothelial cells
- gene expression
- genome wide
- copy number
- induced pluripotent stem cells
- tyrosine kinase
- bone regeneration
- pluripotent stem cells
- cell therapy
- human health
- risk assessment