Molecular mechanisms of long non-coding RNAs in anaplastic thyroid cancer: a systematic review.

Hilda SamimiSayed Mahmoud Sajjadi-JaziSoroush SeifiradRasha AtlasiHabibollah MahmoodzadehMohammad Ali FaghihiVahid Haghpanah

Published in: Cancer cell international (2020)

lncRNAs play a crucial role in regulation of different processes involved in the development and progression of ATC. Currently, just a few lncRNAs have been identified in ATC that may serve as prognosis markers such as GAS5, MIR22HG, and CASC2. Also, because of the dysregulation of Klhl14-AS, HOTAIRM1, and PCA3 during ATC development and progression, they may act as therapeutic targets. However, for most lncRNAs, only a single experiment has evaluated the expression profile in ATC tissues/cells. Therefore, further functional studies and expression profiling is needed to resolve this limitation and identify novel and valid biomarkers.

Keyphrases

long non coding rna
poor prognosis
genome wide identification
network analysis
induced apoptosis
cell proliferation
genome wide analysis
gene expression
cell cycle arrest
cell death
living cells