Restrictive fluids versus standard care in adults with sepsis in the emergency department (REFACED): A multicenter, randomized feasibility trial.
Marie Kristine JessenLars Wiuff AndersenMarie-Louise H ThomsenPeter KristensenWazhma HayeriRanva E HasselTina G MesserschmidtChristoffer G SøllingAnders PernerJens Aage K PetersenHans KirkegaardPublished in: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine (2022)
A protocol restricting IV crystalloid fluids in ED patients with sepsis reduced 24-h fluid volumes compared to standard care. A future trial powered toward patient-centered outcomes appears feasible.
Keyphrases
- emergency department
- phase iii
- phase ii
- double blind
- healthcare
- palliative care
- clinical trial
- open label
- study protocol
- intensive care unit
- acute kidney injury
- quality improvement
- placebo controlled
- septic shock
- randomized controlled trial
- pain management
- current status
- type diabetes
- chronic pain
- adverse drug
- insulin resistance