Rationale and Design of a Genetic Study on Cardiometabolic Risk Factors: Protocol for the Tehran Cardiometabolic Genetic Study (TCGS).

Maryam S Daneshpour Mohammad-Sadegh Fallah Bahareh Sedaghati-Khayat Kamran Guity Davood Khalili Mehdi Hedayati Ahmad Ebrahimi Farhad Hajsheikholeslami Parvin Mirmiran Fahimeh Ramezani Tehrani Amir-Abbas Momenan Arash Ghanbarian Atieh Amouzegar Parisa Amiri Fereidoun Azizi

Published in: JMIR research protocols (2017)

Investigations conducted within the TCGS will seek to identify relevant patterns of genetic polymorphisms that could be related to cardiometabolic risk factors in participants from Tehran. By linking genome-wide data to the existing databank of TLGS participants, which includes comprehensive behavioral, biochemical, and clinical data on each participant since cohort inception in 1999, the TCGS will also allow exploration of gene-gene and gene-environment interactions as they relate to disease status.

Keyphrases

genome wide
risk factors
copy number
dna methylation
randomized controlled trial
big data
genome wide identification
gene expression
machine learning