SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expression.
Najla ArshadMaudry Laurent-RolleWesam S AhmedJack Chun-Chieh HsuSusan M MitchellJoanna B PawlakDebrup SenguptaKabir Hassan BiswasPeter CresswellPublished in: bioRxiv : the preprint server for biology (2022)
m as a viral mechanism of MHC-I down-regulation to facilitate immune evasion.