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METTL14-mediated N6-methyladenosine modification of TCP1 mRNA promotes acute myeloid leukemia progression.

Mengmeng ZhangZhibin XieYuanyuan TanYanping WuMeng WangPingping ZhangYuan YuanJiajia Li
Published in: Cellular signalling (2024)
Upregulation of TCP1 expression in AML through METTL14-mediated m6A modification accelerates the malignant progression of the disease. Therefore, targeting the m6A modification of TCP1 could be a potential therapeutic strategy to enhance the treatment of AML.
Keyphrases
  • acute myeloid leukemia
  • poor prognosis
  • allogeneic hematopoietic stem cell transplantation
  • binding protein
  • cell proliferation
  • signaling pathway
  • acute lymphoblastic leukemia