Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.

Shaoxing Guan Xi Chen Yuru Wei Fei Wang Wen Xie Youhao Chen Heng Liang Xia Zhu Yunpeng Yang Wenfeng Fang Yan Huang Hongyun Zhao Xiao-Xu Zhang Shu Liu Wei Zhuang Min Huang Xue-Ding Wang Li Zhang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

These findings characterized rs3744797 as an oncogenic variant in mediating EGFR-TKI resistance and tumor aggressiveness through deubiquitinating MLLT3, highlighting the variant as a predictive biomarker for EGFR-TKI response in NSCLC.

Keyphrases

tyrosine kinase
small cell lung cancer
epidermal growth factor receptor
advanced non small cell lung cancer
poor prognosis
brain metastases
transcription factor
chronic myeloid leukemia
dna damage
oxidative stress