The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology.

Sophie A I SanfordLauren V C MillerMarina VaysburdSophie KeelingBenjamin J TuckJessica ClarkMichal NeumannVictoria SyandaLeo C JamesWilliam A McEwan

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

Type-I IFN (IFN-I) promotes seeded tau aggregation in neural cultures. IFNAR inhibition prevents IFN-I driven sensitivity to tau aggregation. IFN-I driven vulnerability is intrinsic to neurons. Tau pathology is significantly reduced in aged P301S-tau mice lacking IFNAR.

Keyphrases

cerebrospinal fluid
dendritic cells
immune response
spinal cord
climate change
metabolic syndrome
mouse model