Login / Signup

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease.

Thomas W WinklerFelix GrassmannCaroline BrandlChristina KielFelix GüntherTobias StrunzLorraine WeidnerMartina E ZimmermannChristina A KorbAlicia PoplawskiAlexander K SchusterMartina Müller-NurasyidAnnette PetersFranziska G RauscherTobias ElzeKatrin HornMarkus ScholzMarisa Cañadas-GarreAmy Jayne McKnightNicola QuinnRuth E HoggHelmut KüchenhoffIris M HeidKlaus J StarkBernhard H F Weber
Published in: BMC medical genomics (2020)
Our GWAS on early AMD identified novel loci, highlighted shared and distinct genetics between early and advanced AMD and provides insights into AMD etiology. Our data provide a resource comparable in size to the existing IAMDGC data on advanced AMD genetics enabling a joint view. The biological relevance of this joint view is underscored by the ability of early AMD effects to differentiate the major pathways for advanced AMD.
Keyphrases
  • age related macular degeneration
  • genome wide association
  • systematic review
  • electronic health record
  • genome wide
  • big data
  • randomized controlled trial
  • machine learning
  • data analysis