Computed tomography reveals hypertrophic remodelling of the diaphragm in cystic fibrosis but not in COPD.
Fatemeh OstadanAdamo A DonovanElias MatoukFrancois Gabriel DavidDylan MarchandCaroline ReinholdDao NguyenPeter GoldbergAndrea BenedettiBenjamin M SmithBasil J PetrofPublished in: ERJ open research (2023)
Our data suggest that the CF diaphragm undergoes hypertrophic remodelling, whereas in COPD the nonrespiratory muscles show altered muscle quality consistent with greater lipid content. Thoracic CT can thus identify distinctive respiratory and nonrespiratory muscle remodelling signatures associated with different chronic lung diseases.
Keyphrases
- cystic fibrosis
- lung function
- computed tomography
- chronic obstructive pulmonary disease
- skeletal muscle
- dual energy
- mechanical ventilation
- positron emission tomography
- pseudomonas aeruginosa
- image quality
- contrast enhanced
- spinal cord
- magnetic resonance imaging
- electronic health record
- fatty acid
- air pollution
- genome wide
- dna methylation
- acute respiratory distress syndrome
- big data
- quality improvement
- magnetic resonance
- machine learning