Validation of the 12-gene Predictive Signature for Adjuvant Chemotherapy Response in Lung Cancer.
Yang XieWei LuShidan WangXiming TangHao TangYunyun ZhouCesar MoranCarmen BehrensJack A RothQinghua ZhouDavid H JohnsonStephen G SwisherJohn Victor HeymachVassiliki A PapadimitrakopoulouGuanghua XiaoJohn D MinnaIgnacio I WistubaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
This study validated that the 12-gene signature and the FFPE-based clinical assay predict that patients whose resected lung adenocarcinomas exhibit an adjuvant chemotherapy benefit gene expression pattern and who then receive adjuvant chemotherapy have significant survival advantage compared with patients whose tumors exhibit the benefit pattern but do not receive adjuvant chemotherapy.