Combined immunotherapy with controlled Interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: an open-label, multi-institutional phase 1 trial.

E Antonio ChioccaArnold B GelbClark C ChenGanesh RaoDavid A ReardonPatrick Y WenWenya Linda BiPierpaolo PeruzziChristina AmideiDan TriggsLeah SeftenGrace ParkJames GrantKyla TrumanJill Y BuckNira HadarNathan DemarsJohn MiaoTaylor EstupinanJohn LoewyKamal ChadhaJoseph TringaliLaurence CooperRimas V Lukas

Published in: Neuro-oncology (2021)

The safety of this combination immunotherapy was established and has led to an ongoing phase 2 clinical trial of immune checkpoint blockade with controlled IL-12 gene therapy (NCT04006119).

Keyphrases

gene therapy
clinical trial
open label
double blind
phase ii
randomized controlled trial
phase iii