A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells.

Takashi TakedaYuhki Yokoyama Hidekazu Takahashi Daisuke OkuzakiKaho AsaiHiroaki ItakuraNorikatsu MiyoshiShogo KobayashiMamoru UemuraToshitsugu FujitaHiroo UenoMasaki MoriYuichiro DokiHodaka FujiiHidetoshi EguchiHirofumi Yamamoto

Published in: British journal of cancer (2021)

Our data propose the mechanistic insight that the KLF5 protein constructs the core-regulatory circuitry with co-factors in the three-dimensional genome structure and coordinately regulates KLF5 and CCAT1 expression in CRC.

Keyphrases

transcription factor
stem cells
poor prognosis
genome wide
electronic health record
big data
amino acid
machine learning
long non coding rna
small molecule
deep learning