Sorting Nexins: Role in The Regulation of Blood Pressure.
Juan HuangAndrew C TiuPedro A JoseJian YangPublished in: The FEBS journal (2021)
Sorting nexins (SNXs) are a family of proteins that regulate cellular cargo sorting and trafficking, maintain intracellular protein homeostasis, and participate in intracellular signaling. SNXs are also important in the regulation of blood pressure, via several mechanisms. Aberrant expression and dysfunction of SNXs participate in the dysregulation of blood pressure. Genetic studies show correlation between SNX gene variants and response to antihypertensive drugs. In this review, we summarize the progress in SNX-mediated regulation of blood pressure, discuss the potential role of SNXs in the pathophysiology and treatment of hypertension, and propose novel strategies for the medical therapy of hypertension.
Keyphrases
- blood pressure
- hypertensive patients
- heart rate
- copy number
- poor prognosis
- genome wide
- blood glucose
- healthcare
- reactive oxygen species
- oxidative stress
- binding protein
- metabolic syndrome
- gene expression
- adipose tissue
- mesenchymal stem cells
- weight loss
- climate change
- skeletal muscle
- cell therapy
- replacement therapy
- genome wide identification